9563. TPMPA
Nomenclature
CAS number: 182485-36-5
Methyl (1,2,3,6-tetrahydro-4-pyridinyl)phosphinic acid; (1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid. C6H12NO2P; mol wt 161.14.
C 44.72%, H 7.51%, N 8.69%, O 19.86%, P 19.22%.
Description and references
Selective antagonist for GABAc receptors. Prepn: Y. Murata et al., Bioorg. Med. Chem. Lett. 6, 2073 (1996); R. Miledi et al., US 5627169 (1997 to Univ. California). Design and in vitro pharmacology: D. Ragozzino et al., Mol. Pharmacol. 50, 1024 (1996). Specificity vs human receptors and alternate synthesis: M. Chebib et al., Eur. J. Pharmacol. 357, 227 (1998). Use as antagonist: A. Rozzo et al., Neuroscience 90, 1085 (1999).
