9578. Traxanox

Nomenclature

CAS number: 58712-69-9
9-Chloro-7-(1H-tetrazol-5-yl)-5H-[1]benzopyrano[2,3-b]pyridin-5-one; 9-chloro-7-(5-1H-tetrazolyl)-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine.
C13H6ClN5O2; mol wt 299.67.
C 52.10%, H 2.02%, Cl 11.83%, N 23.37%, O 10.68%.

Description and references

Antiallergic agent which selectively inhibits release of allergic mediators from mast cells. Prepn: T. Oe, M. Tsuruda, DE 2521980; eidem, US 4085111 (1975, 1978 both to Yoshitomi). Antianaphylactic activity in animals: K. Goto et al., Jpn. J. Pharmacol. 30, 537 (1980). Mechanism of action study: K. Goto et al., Int. Arch. Allergy Appl. Immunol. 68, 332 (1982). Clinical pharmacology and pharmacokinetics: A. Ebihara et al., Arzneim.-Forsch. 37, 1388 (1987). Metabolism in humans: M. Tateno et al., Yakuri to Chiryo 16, 3251 (1988), C.A. 110, 18040n (1989).

Chemical structure

Properties

mp >300°.

Derivative

Sodium salt pentahydrate.

Nomenclature

Y-12141; Clearnal (Yoshitomi).
C13H5ClN5NaO2.5H2O; mol wt 411.73.
C 37.92%, H 3.67%, Cl 8.61%, N 17.01%, Na 5.58%, O 27.20%.

Therapeutic Category

Antiallergic; antiasthmatic.

Keywords

Antiallergic; Antiasthmatic (Nonbronchodilator)