9582. Tremorine

Nomenclature

CAS number: 51-73-0
1,1′-(2-Butyne-1,4-diyl)bispyrrolidine; 1,1′-(2-butynylene)dipyrrolidine; 1,4-dipyrrolidino-2-butyne.
C12H20N2; mol wt 192.30.
C 74.95%, H 10.48%, N 14.57%.

Description and references

Prepn from pyrrolidine + 1,4-dichloro-2-butyne: Maier, DE 896810 (1953 to BASF); Reppe et al., Ann. 596, 79 (1955); Biel, DiPierro, J. Am. Chem. Soc. 80, 4609 (1958). Review of chemical and biological studies: Karlen, Acta Pharm. Suec. 1970, 169-200; see also Kolla, Obvintseva, Farmakol. Toksikol. 36, 736-745 (1973).

Chemical structure

Properties

Liquid. bp2.5 116-116.5°; bp 0.1 93-95°.

Derivative

Methiodide.
C12H20N2.2CH3I; mol wt 476.18.
C 35.31%, H 5.50%, N 5.88%, I 53.30%.

Properties

Crystals, mp 239-240°.

Use

To produce exptl parkinsonism: Everett et al., Science 124, 79 (1956).