9585. Trepibutone

Nomenclature

CAS number: 41826-92-0
2,4,5-Triethoxy-γ-oxobenzenebutanoic acid; 3-(2,4,5-triethoxybenzoyl)propionic acid; AA-149; Supacal (Lederle).
C16H22O6; mol wt 310.34.
C 61.92%, H 7.15%, O 30.93%.

Description and references

Prepn: T. Murata et al., DE 2244324 corresp to US 3943169 (1973, 1976 both to Takeda). Properties and stabilities: M. Mitani et al., Takeda Kenkyushoho 36, 206 (1977), C.A. 88, 126284f (1978). Pharmacokinetics: eidem, ibid. 215, C.A. 88, 115067m (1978). Biotransformation: T. Kobayashi et al., Xenobiotica 8, 535 (1978). Metabolism studies: S. Tanayama et al., ibid. 365, 377. Spasmolytic action in dogs: H. Satoh et al., Eur. J. Pharmacol. 48, 309 (1978). Mechanism of choleretic action: eidem, ibid. 125. Toxicity studies: S. Sato et al., Takeda Kenkyushoho 36, 263 (1977), C.A. 88, 11535x (1978).

Chemical structure

Properties

Colorless needles from aq ethanol or plates from aq acetone, mp 150-151°. Stable to heat, humidity, indoor diffused sunlight. Aq solns heated to 100° for 10 hr showed no degradation.

Therapeutic Category

Choleretic; antispasmodic.

Keywords

Antispasmodic; Choleretic