9672. Triethylenephosphoramide

Nomenclature

CAS number: 545-55-1
1,1′,1″-Phosphinylidynetrisaziridine; tris(1-aziridinyl)phosphine oxide; phosphoric acid triethyleneimide; aphoxide; APO; TEPA.
C6H12N3OP; mol wt 173.15.
C 41.62%, H 6.99%, N 24.27%, O 9.24%, P 17.89%.

Description and references

Prepn: Bestian, Ann. 566, 231 (1950). Toxicity study: Gaines, Toxicol. Appl. Pharmacol. 14, 515 (1969).

Chemical structure

Properties

Crystals, mp 41°. bp23 90-91°. Extremely sol in water. Very sol in alcohol, ether, acetone. LD50 orally in male rats: 37 mg/kg (Gaines).

Use

Insect chemosterilant; in dyeing, creaseproofing and flameproofing textiles; stabilizer for polymers; in photographic emulsion hardening.

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic; Alkylating Agents; Ethylenimines and Methylmelamines