Nomenclature
CAS number: 75-89-8
2,2,2-Trifluoroethanol; TFE; 2,2,2-trifluoroethyl alcohol.
C
2H
3F
3O; mol wt 100.04.
C 24.01%, H 3.02%, F 56.97%, O 15.99%.
CF
3CH
2OH.
Description and references
Weakly acidic alcohol. Prepn: F. Swarts, Bull. Soc. Chim. Belg. 43, 471
(1934). Structural study: L. A. Curtiss et al., J. Am. Chem. Soc. 100, 79 (1978).
Interaction with peptides and proteins: R. Rajan, P. Balaram, Int. J. Pept. Protein Res. 48,
328 (1996). Review of production and applications: S. Arai, Spec. Chem. 18, 294-297 (1998);
of effects on peptide and protein structures: M. Buck, Q. Rev. Biophys. 31, 297-355 (1998).
Properties
Transparent, colorless liquid, odor similar to
ethanol; bp 74.05°; mp 43.5°. d0 1.4106. d22 1.3739.
nD22 1.2907. pK 12.4. Dielectric constant: 26.67. Dipole
moment: 2.52 D. Miscible with water, alcohols, ethers, ketones,
chloroform.Use
In synthesis of medical anaesthetics, pharmaceuticals,
and agrochemicals; in polymerizations. Protein denaturant; stabilizes
peptide structures. Cleaning solvent; eluent in HPLC separations;
working fluid in Rankine heat cycle systems. Environmentally friendly
alternative to CFCs.