9684. Trifluperidol

Nomenclature

CAS number: 749-13-3
1-(4-Fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidinyl]-1-butanone; 4′-fluoro-4-[4-hydroxy-4-(α,α,α-trifluoro-m-tolyl)piperidino]butyrophenone; p-fluoro-4-[4′-hydroxy-4′-(3″-trifluoromethyl)phenyl]piperidinobutyrophenone; 1-(3′-p-fluorobenzoylpropyl)-4-hydroxy-4-(3″-trifluoromethylphenyl)piperidine; ω-[4-hydroxy-4-(m-trifluoromethylphenyl)piperidino]-p-fluorobutyrophenone; flumoperone.
C22H23F4NO2; mol wt 409.42.
C 64.54%, H 5.66%, F 18.56%, N 3.42%, O 7.82%.

Description and references

Prepn: P. A. J. Janssen, GB 895309; idem, US 3438991 (1962, 1969 both to Janssen). Pharmacology: idem, Arzneim.-Forsch. 11, 932 (1961).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 2062-77-3
R-2498; Psicoperidol (Lusofarmaco); Psychoperidol (Ethnor); Triperidol (Janssen).
C22H23F4NO2.HCl; mol wt 445.88.
C 59.26%, H 5.43%, F 17.04%, N 3.14%, O 7.18%, Cl 7.95%.

Properties

Crystals from acetone, mp 200.5-201.3°. Sol in water. LD50 in rats (mg/kg): 14 i.v.; 70 s.c. (Janssen, 1961).

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Butyrophenones