9704. Trimeprazine

Nomenclature

CAS number: 84-96-8
N,N,β-Trimethyl-10H-phenothiazine-10-propanamine; 10-[3-(dimethylamino)-2-methylpropyl]phenothiazine; 10-(2-methyl-3-dimethylaminopropyl)phenothiazine; alimemazine; methylpromazine; Bayer 1219; RP-6549.
C18H22N2S; mol wt 298.45.
C 72.44%, H 7.43%, N 9.39%, S 10.74%.

Description and references

Prepn: Jacob, Robert, US 2837518 (1958 to Rhne-Poulenc). Metabolism studies: Robinson, J. Pharm. Pharmacol. 18, 19 (1966).

Chemical structure

Properties

Crystals, mp 68°. bp0.3 150-175°.

Derivative

Tartrate.

Nomenclature

CAS number: 4330-99-8
Panectyl (RPR); Repeltin (Fabre-Medikosma); Temaril (Allergan); Theralene (Rhne-Poulenc); Vallergan (M & B).
(C18H22N2S)2.C4H6O6; mol wt 746.98.
C 64.32%, H 6.75%, N 7.50%, S 8.59%, O 12.85%.

Properties

Crystals. Sol in water; slightly sol in alcohol.

Therapeutic Category

Antipruritic.

Therapeutic Category (Veterinary)

Antipruritic.

Keywords

Antipruritic