9760. Trithiozine

Nomenclature

CAS number: 35619-65-9
4-[Thioxo(3,4,5-trimethoxyphenyl)methyl]morpholine; 4-(3,4,5-trimethoxythiobenzoyl)morpholine; sulmetozine (rescinded INN); tritiozine; ISF-2001; Tresanil (ISF).
C14H19NO4S; mol wt 297.37.
C 56.55%, H 6.44%, N 4.71%, O 21.52%, S 10.78%.

Description and references

Non-anticholinergic gastric secretion inhibitor. Prepn: G. Pifferi, DE 2102246; idem, US 3862138 (1972, 1975 both to ISF). Synthesis and pharmacology: G. Pifferi et al., Chim. Ther. 8, 462 (1973). HPLC determn in plasma and urine: T. Crolla et al., J. Chromatogr. 222, 257 (1981). Clinical studies: M. Elakovic et al., J. Int. Med. Res. 8, 347 (1980); U. Marini et al., Clin. Ter. 92, 399 (1980). Evaluation of gastric acid suppression: K. Gibinski, Curr. Med. Res. Opin. 7, 516 (1981).

Chemical structure

Properties

Pale yellow solid from ethanol, mp 141-143°. LD50 i.p. in mice: 2000 mg/kg (Pifferi, 1973).

Therapeutic Category

Antisecretory (gastric).

Keywords

Antiulcerative