9829. Tybamate

Nomenclature

CAS number: 4268-36-4
Butylcarbamic acid 2-[[(aminocarbonyl)oxy]methyl]-2-methylpentyl ester; carbamate of 2-(hydroxymethyl)-2-methylpentyl ester of butylcarbamic acid; N-butyl-2-methyl-2-propyl-1,3-propanediol dicarbamate; 2-methyl-2-propyltrimethylene butylcarbamate carbamate; Nospan (Johnsons); Solacen (Wallace Labs.); Tybatran (Robins).
C13H26N2O4; mol wt 274.36.
C 56.91%, H 9.55%, N 10.21%, O 23.33%.

Description and references

Prepd from 2-methyl-2-propyl-3-hydroxypropyl carbamate + butyl isocyanate: Berger, Ludwig, US 2937119 (1960 to Carter Prod.). Comprehensive description: P. Reisberg et al., Anal. Profiles Drug Subs. 4, 494-515 (1975).

Chemical structure

Properties

Crystals from 1,1,2-trichloroethane + hexane (1:2), mp 49-51°, bp0.06 150-152°.

Therapeutic Category

Anxiolytic.

Keywords

Anxiolytic; Carbamates