9849. Unoprostone

Nomenclature

CAS number: 120373-36-6
(5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-(3-oxodecyl)cyclopentyl]-5-heptenoic acid; 13,14-dihydro-15-keto-20-ethyl-PGF2α.
C22H38O5; mol wt 382.53.
C 69.08%, H 10.01%, O 20.91%.

Description and references

Prepn: R. Ueno et al., EP 289349; eidem, US 5221763 (1988, 1993 both to Ueno). Pharmacological characterization: Y. Goh, J. Kishino, Jpn. J. Ophthalmol. 38, 236 (1994). Mechanism of action study: M. Sakurai et al., ibid. 37, 252 (1993). Comparative clinical trial in glaucoma and ocular hypertension: J.-P. Nordmann et al., Am. J. Ophthalmol. 133, 1 (2002).

Chemical structure

Derivative

Isopropyl ester.

Nomenclature

CAS number: 120373-24-2
UF-021; Rescula (Novartis).
C25H44O5; mol wt 424.61.
C 70.72%, H 10.44%, O 18.84%.

Therapeutic Category

Antiglaucoma; in treatment of ocular hypertension.

Keywords

Antiglaucoma; Prostaglandin/Prostaglandin Analog