Description and references

Natriuretic hormone produced by the kidney and secreted into the urine; regulates sodium and water reabsorption in the medullary collecting duct. Derived from the same prohormone as atrial natriuretic peptide, q.v., with similar pharmacological effects. Isoln from human urine: P. Schulz-Knappe et al., Klin. Wochenschr. 66, 752 (1988). RIA determn in biological samples: C. Drummer et al., Pfluegers Arch. 423, 372 (1993). Role in body fluid regulation: C. Drummer, Semin. Nephrol. 21, 239 (2001). Review of pharmacology and clinical implications: W.-G. Forssmann et al., Cardiovasc. Res. 51, 450-462 (2001). Comparison of biological actions of natriuretic peptides in experimental heart failure: H. H. Chen et al., Am. J. Physiol. Regul. Integr. Comp. Physiol. 288, 1093 (2005).

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