10023. Vitamin K5

Nomenclature

CAS number: 83-70-5
4-Amino-2-methyl-1-naphthalenol; 4-amino-2-methyl-1-naphthol; 2-methyl-4-amino-1-hydroxynaphthalene; 3-methyl-4-hydroxy-1-naphthylamine; Synkamin (Parke-Davis).
C11H11NO; mol wt 173.21.
C 76.28%, H 6.40%, N 8.09%, O 9.24%.

Description and references

Prepn: Sah, Rec. Trav. Chim. 59, 458 (1940); 60, 373 (1941); Veldstra, Wiardi, ibid. 61, 547 (1942); 62, 75 (1943). Insulin-mimicking effect on glucose transport: J. N. Livingston et al., Am. J. Physiol. 234, E484 (1978). Polargraphic determn in aq soln: K. Takamura, F. Watanabe, Methods Enzymol. 67, 134 (1980).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 130-24-5
C11H11NO.HCl; mol wt 209.67.
C 63.01%, H 5.77%, N 6.68%, O 7.63%, Cl 16.91%.

Properties

Needles from dil HCl, darkens at 262°, dec 280-282°. Turns pink to dark violet on exposure to air and light. Freely sol in water; slightly sol in alc. Insol in ether.

Use

Chemical probe to study insulin-activated hexose transport.

Therapeutic Category

Vitamin (prothrombogenic).

Keywords

Vitamin/Vitamin Source; Vitamin K