10027. Voacamine

Nomenclature

CAS number: 3371-85-5
12-Methoxy-13-[(3α)-17-methoxy-17-oxovobasan-3-yl]ibogamine-18-carboxylic acid methyl ester; voacanginine.
C43H52N4O5; mol wt 704.90.
C 73.27%, H 7.44%, N 7.95%, O 11.35%.

Description and references

Bisindole alkaloid found in Voacanga africana Stapf., V. thouarsii R. & Sch., var obtusa (K. Sch.) Pichon and V. schweinfurthii Staph., Apocynaceae: Janot, Goutarel, Compt. Rend. 240, 1719 (1955); Rao, J. Org. Chem. 23, 1455 (1958); Janot, Goutarel, US 2823204 (1958 to Lab. Gobey). Identity with voacanginine: LeBarre, Gillo, Bull. Acad. R. Med. Belg. 20, 194 (1956). Cleaved by acid catalysis to voacangine: Winkler, Naturwissenschaften 48, 694 (1961). Structure: Goutarel et al., Compt. Rend. 243, 1670 (1956); Percheron, Ann. Chim. (Paris) 4, 303 (1959); Büchi et al., J. Am. Chem. Soc. 85, 1893 (1963). Review: Gorman et al. in The Alkaloids 1, J. E. Saxton, Ed. (The Chem. Soc., London, 1971) pp 242-249.

Chemical structure

Properties

Prisms from acetone + methanol, dec 223°. [α]D20 52° (chloroform). uv max: 225, 295 nm (log ε 4.72, 4.28). Sol in chloroform, acetone; slightly sol in methanol, ethanol.

Derivative

Voacangine.

Nomenclature

Carbomethoxyibogaine; 12-methoxyibogamine-18-carboxylic acid methyl ester.
C22H28N2O3; mol wt 368.47.
C 71.71%, H 7.66%, N 7.60%, O 13.03%.

Description and references

Structure: Bartlett et al., J. Am. Chem. Soc. 80, 126 (1958).

Properties

Prismatic needles from ethanol, mp 136-137°. Sublimes0.01 135°. [α]D20 42° (c = 1.26 in chloroform). pKa 7.4 (40% aq methanol); pKa 5.73 (33% DMF). uv max (methanol): 225, 287 300 nm (log ε 4.43, 3.97, 3.93). Freely sol in acetone, chloroform; slightly sol in methanol, ethanol.