10036. VX

Nomenclature

CAS number: 50782-69-9
Methylphosphonothioic acid S-[2-[bis(1-methylethyl)amino]ethyl] O-ethyl ester; O-ethyl S-[2-(diisopropylamino)ethyl]methylphosphonothioate; Tx 60.
C11H26NO2PS; mol wt 267.37.
C 49.41%, H 9.80%, N 5.24%, O 11.97%, P 11.58%, S 11.99%.

Description and references

Nerve gas. Prepn: R. V. Ley, G. L. Sainsbury, GB 1346409; A. W. Wardrop, C. Stratford, GB 1346410 (both 1974 to U.K. Sec. of State for Defence), C.A. 81, 4068y, 4069z (1974); S. R. Eckhaus et al., US 3911059 (1975 to U.S.A. Sec. for Army). Activity studies in humans: F. R. Sidell, W. A. Groff, Toxicol. Appl. Pharmacol. 27, 241 (1974); F. N. Craig et al., J. Invest. Dermatol. 68, 357 (1977). Toxicity study: J. J. Gordon, L. Leadbeater, Toxicol. Appl. Pharmacol. 40, 109 (1977).

Chemical structure

Properties

Nonvolatile, odorless liquid. pKa′ 7.9. LD50 s.c. in rabbits: 15.4 μg/kg (Gordon, Leadbeater).

Caution

Cholinesterase inhibitor; more potent than sarin, q.v.

Use

Chemical warfare agent.