10048. Withaferin A

Description and references

Isolated from the leaves of Withania somnifera Dun., Solanaceae: Lavie, Yarden, J. Chem. Soc. 1962, 2925; Kirson et al., Tetrahedron 26, 2209 (1970); Subramanian, Sethi, Indian J. Pharm. 32, 16 (1970); from roots of Withania coagulans: eidem, Curr. Sci. 38, 267 (1969); from Acnistus arborescens (L.): Kupchan et al., J. Org. Chem. 34, 3858 (1969). Structure: Lavie et al., J. Chem. Soc. 1965, 7517; Kupchan, loc. cit. Crystal structure: McPhail, Sim, J. Chem. Soc. C 1968, 962. Antitumor activity studies: B. Shohat et al., Cancer Chemother. Rep. 51, 271 (1967); B. Shohat, H. Joshua, Int. J. Cancer 8, 487 (1971). Synthetic studies: M. Hirayama et al., J. Chem. Soc. Perkin Trans. 1 1981, 88. Stereoselective synthesis: eidem, Tetrahedron Lett. 23, 4725 (1982).

Properties