10080. Xylazine

Nomenclature

CAS number: 7361-61-7
N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine; 5,6-dihydro-2-(2,6-xylidino)-4H-1,3-thiazine; 2-(2,6-dimethylphenylamino)-4H-5,6-dihydro-1,3-thiazine; Bay 1470; BayVa 1470; Wh-7286.
C12H16N2S; mol wt 220.33.
C 65.41%, H 7.32%, N 12.71%, S 14.55%.

Description and references

Prepn: O. Behner et al., BE 634552 C.A. 61, 4369b (1964); eidem, DE 1173475 C.A. 61, 13323c (1964); eidem, US 3235550 (1964, 1964, 1966 all to Bayer). Pharmacology: G. Sagner et al., Dtsch. Tieraerztl. Wochenschr. 75, 565 (1968); Kroneberg, Schlossman, Arch. Pharmakol. Exp. Pathol. 268, 348 (1971). Metabolic studies: Duhm et al., Berl. Muench. Tieraerztl. Wochenschr. 82, 104 (1969). Veterinary clinical studies: Clarke, Hall, Vet. Rec. 85, 512 (1969); Burns, McMullan, Vet. Med. 67, 77 (1972).

Chemical structure

Properties

Colorless, almost tasteless crystals from benzene-ligroin, mp 140-142°. Also reported as mp 136-139°. Soluble in dilute acids, benzene, acetone, chloroform; sparingly sol in petr ether. Practically insol in water, alkalies. LD50 in mice (mg/kg): 43 i.v.; 121 s.c.; 240 orally; LD50 in rats (mg/kg): 130 orally (Sagner).

Derivative

Hydrochloride.

Nomenclature

CAS number: 23076-35-9
Narcoxyl (Veterinaria); Rompun (Bayer); Solvazine (Solvay); Xylapan (Chassot); Xylasol (Graeub).
C12H16N2S.HCl; mol wt 256.79.
C 56.13%, H 6.67%, N 10.91%, S 12.49%, Cl 13.81%.

Therapeutic Category (Veterinary)

Sedative, analgesic, muscle relaxant.