10188. Zolimidine

Nomenclature

CAS number: 1222-57-7
2-[4-(Methylsulfonyl)phenyl]imidazo[1,2-a]pyridine; zoliridine; Solimidin (Selvi).
C14H12N2O2S; mol wt 272.32.
C 61.75%, H 4.44%, N 10.29%, O 11.75%, S 11.77%.

Description and references

Gastroprotective agent. Prepn: GB 991589; L. Almirante et al., US 3318880 (1965, 1967 both to Selvi); eidem, J. Med. Chem. 8, 305 (1965). Metabolism: eidem, Farmaco Ed. Sci. 29, 941 (1974). Series of articles on pharmacology: Panminerva Med. 16, 301-359 (1974). Pharmacokinetics: E. Schraven, D. Trottnow, Arzneim.-Forsch. 26, 213 (1976). Clinical mucopoietic activity: S. Abate et al., Int. J. Tissue React. 4, 319 (1982); M. C. Parodi et al., Scand. J. Gastroenterol. 19, Suppl. 92, 163 (1984). Clinical study: A. Materia et al., Clin. Ter. 97, 183 (1981).

Chemical structure

Properties

Crystals, mp 242-244°. LD50 orally in rats: 3710 mg/kg (Almirante, 1967).

Therapeutic Category

Antiulcerative.

Keywords

Antiulcerative; Cytoprotectant (Gastric)