10210. Otamixaban
Nomenclature
CAS number: 193153-04-7
(αR)-3-(Aminoiminomethyl)-α-[(1R)-1-[[4-(1-oxido-4-pyridinyl)benzoyl]amino]ethyl]benzenepropanoic
acid methyl ester; methyl (2R,3R)-2-[3-amidinobenzyl]-3-[[4-(1-oxido-4-pyridinyl)benzoyl]amino]butanoate; (2R)-(3-carbamoylimidoylbenzyl)-(3R)-[4-(1-oxypyridin-4-yl)benzoylamino]butryic
acid methyl ester; FXV-673; RPR-130673; XRP-0673. C25H26N4O4; mol wt 446.50.
C 67.25%, H 5.87%, N 12.55%, O 14.33%.
Description and references
Direct inhibitor of Factor Xa. Prepn: K. R. Guertin et al., WO 97 24118; S. I. Klein et al., US 6080767 (1997, 2000 both to Rhone Poulenc Rorer); K. R. Guertin et al., Bioorg. Med. Chem. Lett. 12, 1671 (2002) DOI PubMed. Pharmacology: V. Chu et al., Thromb. Res. 103, 309 (2001) DOI PubMed. Clinical pharmacokinetics: A. Paccaly et al., J. Clin. Pharmacol. 46, 37 (2006) DOI PubMed; and evaluation in coronary artery disease: M. Hinder et al., Clin. Pharmacol. Ther. 80, 691 (2006) DOI PubMed. Review: E. A. Nutescu, K. Pater, IDrugs 9, 854-865 (2006) PubMed.
Therapeutic Category
Antithrombotic.
Keywords
Antithrombotic