10222. Imisopasem Manganese

Nomenclature

CAS number: 218791-21-0
(PB-7-11-2344′3′)-Dichloro[(4aR,13aR,17aR,21aR)-1,2,3,4,4a,5,6,12,13,13a,14,15,16,17,17a,18,19,20,21,21a-eicosahydro-11,7-nitrilo-7H-dibenzo[b,h][1,4,7,10]tetraazacycloheptadecine-κN5,κN13,κN18,κN21,κN22]manganese; manganese(II)dichloro[(4R,9R,14R,19R)-3,10,13,20,26-pentaazatetracyclo[20.3.1.0.4,9014,19]hexacosa-1(26),22(23),24-triene]; M-40403; SC-72325.
C21H35Cl2MnN5; mol wt 483.38.
C 52.18%, H 7.30%, Cl 14.67%, Mn 11.37%, N 14.49%.

Description and references

Synthetic catalyst that mimics the bioactivity of superoxide dismutase (SOD), q.v.; selectively removes superoxide anions, does not react with nitric oxide, peroxynitrite or hydrogen peroxide. Prepn and SOD activity: K. W. Ashton et al., WO 9302090 (1993 to Monsanto); D. P. Riley et al., US 5637578 (1997); D. Salvemini et al., Science 286, 304 (1999) DOI PubMed. Pharmacological effect on the inflammatory cascade: idem et al., Br. J. Pharmacol. 132, 815 (2001) DOI PubMed; on inflammatory pain: Z. Wang et al., J. Pharmacol. Exp. Ther. 309, 869 (2004) DOI PubMed. Review of pharmacology and therapeutic potential: M. Di Napoli, F. Papa, IDrugs 8, 67-76 (2005) PubMed.

Chemical structure

Properties

Crystals from water.

Therapeutic Category

Anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal)