10224. Indolicidin

Nomenclature

CAS number: 140896-21-5
l-Isoleucyl-l-leucyl-l-prolyl-l-tryptophyl-l-lysyl-l-tryptophyl-l-prolyl-l-tryptophyl-l-tryptophyl-l-prolyl-l-tryptophyl-l-arginyl-l-argininamide.
C100H132N26O13; mol wt 1906.28.
C 63.01%, H 6.98%, N 19.10%, O 10.91%.

Description and references

Cationic antimicrobial peptide of the cathelicidin family. Isolated from bovine neutrophils; has physiological role in host defense. Active vs Gram-negative and -positive bacteria, fungi, and protozoa. Named for its indole-rich structure, composed of 39% tryptophan and 23% proline. Identification: M. E. Selsted et al., J. Biol. Chem. 267, 4292 (1992) PubMed. Synthesis: R. J. Van Abel et al., Int. J. Pept. Protein Res. 45, 401 (1995) PubMed. Structural study in detergent micelles: A. Rozek et al., Biochemistry 39, 15765 (2000) DOI PubMed. Interaction with microbial cell membrane: T. J. Falla et al., J. Biol. Chem. 271, 19298 (1996) DOI PubMed; J. E. Shaw et al., J. Struct. Biol. 154, 42 (2006) DOI PubMed; with target cell DNA: C.-H. Hsu et al., Nucleic Acids Res. 33, 1053 (2005) DOI PubMed.

Chemical structure