Description and references

Selective relaxant binding agent (SRBA). Cyclodextrin-based host molecule that reverses the action of steroidal neuromuscular blocking drugs via selective binding and encapsulation. Prepn: M. Zhang et al., WO 0140316; eidem, US 6670340 (2001, 2003 both to Akzo Nobel). Synthesis, structure-activity, and x-ray crystallography: J. M. Adam et al., J. Med. Chem. 45, 1806 (2002) DOI PubMed. Crystal structure of complex with rocuronium: A. Bom et al., Angew. Chem. Int. Ed. 41, 266 (2002) DOI. LC/MS determn in plasma and urine: O. Epemolu et al., Rapid Commun. Mass Spectrom. 16, 1946 (2002) DOI PubMed. Clinical pharmacokinetics and safety assessment: F. Gijsenbergh et al., Anesthesiology 103, 695 (2005) DOI PubMed. Series of articles on pharmacology and clinical experience: Anesth. Analg. 104, 555-586 (2007) DOI PubMed.

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