10231. Rusalatide

Nomenclature

CAS number: 497221-38-2
l-Alanylglycyl-l-tyrosyl-l-lysyl-l-prolyl-l-α-aspartyl-l-α-glutamylglycyl-l-lysyl-l-arginylglycyl-l-α-aspartyl-l-alanyl-l-cysteinyl-l-α-glutamylglycyl-l-α-aspartyl-l-serylglycylglycyl-l-prolyl-l-phenylalanyl-l-valinamide; TP508; TRAP-508.
C97H147N29O35S; mol wt 2311.44.
C 50.40%, H 6.41%, N 17.57%, O 24.23%, S 1.39%.

Description and references

Synthetic, 23 amino acid peptide corresponding to the nonproteolytic receptor binding domain of human thrombin (prothrombin amino acids 508-530). Stimulates angiogenesis, revascularization, osteogenesis, and tissue repair. Synthesis and identification as thrombin receptor binding site: D. H. Carney, K. C. Glenn, WO 8803151 (1988 to Board of Regents, Univ. Texas); eidem, US 5352664 (1994 to Board of Regents, Univ. Texas; Monsanto); K. C. Glenn et al., Pept. Res. 1, 65 (1988) PubMed. Wound healing effects on experimental incisions: D. H. Carney et al., J. Clin. Invest. 89, 1469 (1992) DOI PubMed. Overview of bioactivities and clinical pharmacology: J. T. Ryaby et al., J. Bone Joint Surg. 88, Suppl. 3, 132-139 (2006) DOI PubMed. Clinical trial in treatment of diabetic foot ulcers: C. Fife et al., Wound Repair Regen. 15, 23 (2007) DOI PubMed.

Chemical structure

Derivative

Acetate (3:2).

Nomenclature

CAS number: 875455-82-6
Chrysalin (OrthoLogic).
(C97H147N29O35S)3.2C2H4O2; mol wt 7054.43.
C 50.23%, H 6.42%, N 17.27%, O 24.72%, S 1.36%.

Therapeutic Category

Vulnerary.

Keywords

Vulnerary