10248. Maropitant

Nomenclature

CAS number: 147116-67-4
(2S,3S)-N-[[5-(1,1-Dimethylethyl)-2-methoxyphenyl]methyl]-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine; (2S,3S)-2-benzhydryl-N-(5-tert-butyl-2-methoxybenzyl)quinuclidin-3-amine.
C32H40N2O; mol wt 468.67.
C 82.01%, H 8.60%, N 5.98%, O 3.41%.

Description and references

Selective neurokinin-1 (NK1) receptor antagonist; blocks the action of substance P on the central nervous system. Prepn: F. Ito et al., WO 9221677 (1992 to Pfizer); eidem, US 6222038 (2001). Pharmacokinetics in dogs: H. A. Benchaoui et al., J. Vet. Pharmacol. Ther. 30, 336 (2007) DOI PubMed. Efficacy in dogs in treatment and prevention of emesis: V. A. de la Puente-Redondo et al., J. Small Anim. Pract. 48, 93 (2007) DOI PubMed; of cisplatin-induced emesis: idem et al., Am. J. Vet. Res. 68, 48 (2007) DOI PubMed; D. M. Vail et al., Vet. Comp. Oncol. 5, 38 (2007) DOI.

Chemical structure

Derivative

Citrate monohydrate.

Nomenclature

CAS number: 359875-09-5
CJ-11972; Cerenia (Pfizer).
C32H40N2O.C6H8O7.H2O; mol wt 678.81.
C 67.24%, H 7.42%, N 4.13%, O 21.21%.

Therapeutic Category (Veterinary)

Antiemetic.