Recombinant human lactoferrin produced in Aspergillus niger var. awamori. Antimicrobial, immunomodulatory glycoprotein of 692 amino acids; mol wt ≈80 kDa. Activates natural killer (NK) and lymphokine-activated killer cells; enhances polymorphonuclear cells and macrophage cytotoxicity. Prepn: D. R. Headon et al., WO 9013642 (1990 to Granada Biosciences); O. M. Conneely et al., US 5849881 (1998 to Baylor College of Med.); and antibacterial activity: P. P. Ward et al., Biotechnology 13, 498 (1995) DOI PubMed. Overview of development: J. H. Andersen, Curr. Opin. Mol. Ther. 6, 344 (2004) PubMed. Clinical evaluation of wound healing properties: T. E. Lyons et al., Am. J. Surg. 193, 49 (2007) DOI PubMed. Clinical efficacy in metastatic cancers: T. G. Hayes et al., Invest. New Drugs 24, 233 (2006) DOI PubMed; E. Jonasch et al., Cancer 113, 72 (2008) DOI PubMed.
Immunomodulator.
Immunomodulator