12-00278. Allopregnane-3β,17α,20α-triol [Archived]

Nomenclature

CAS number: 570-50-3
5α-Pregnane-3β,17,20α-triol; 3β,17,20α-trihydroxy-5α-pregnane; Reichstein's substance O.
C21H36O3; mol wt 336.51.
C 74.95%, H 10.78%, O 14.26%.

Description and references

Isoln from adrenal glands: Steiger, Reichstein, Helv. Chim. Acta 21, 546 (1938). Prepn from allopregn-16-en-3β-ol-20-one: Plattner et al., ibid. 31, 2210 (1948); Julian et al., US 2662904 (1953 to Glidden).

Properties

Leaflets from dil methanol, mp 222-223°. [α]D20 12.55° (c = 1.195 in methanol).

Derivative

3,20-Diacetate.
C25H40O5; mol wt 420.58.
C 71.39%, H 9.59%, O 19.02%.

Properties

Crystals by sublimation, mp 252°. [α]D21 30.1° (c = 1.097 in acetone).

Status

This monograph has been retired and is no longer subject to revision or update.