12-00416. Amicibone [Archived]

Nomenclature

CAS number: 23271-63-8
1-[2-(Hexahydro-1H-azepin-1-yl)ethyl]-2-oxocyclohexanecarboxylic acid phenylmethyl ester; 2-(β-hexamethyleniminoethyl)cyclohexanone-2-carboxylic acid benzyl ester.
C22H31NO3; mol wt 357.49.
C 73.91%, H 8.74%, N 3.92%, O 13.43%.

Description and references

Prepn: BE 639472; BE 639473; Frank et al., AT 237593 (all 1964 to Biochemie GmbH), C.A. 62, 5207e (1965).

Chemical structure

Derivative

Hydrochloride.
C22H31NO3.HCl; mol wt 393.95.
C 67.07%, H 8.19%, N 3.56%, O 12.18%, Cl 9.00%.

Properties

Crystalline powder, mp 136-137°. Sol in water, ethanol and other common organic solvents.

Therapeutic Category

Antitussive.

Keywords

Antitussive

Status

This monograph has been retired and is no longer subject to revision or update.