12-00455. Aminochlorthenoxazin [Archived]

Nomenclature

CAS number: 3567-76-8
6-Amino-2-(2-chloroethyl)-2,3-dihydro-4H-1,3-benzoxazin-4-one; 2-(β-chloroethyl)-2,3-dihydro-4-oxo-6-amino-1,3-benzoxazine.
C10H11ClN2O2; mol wt 226.66.
C 52.99%, H 4.89%, Cl 15.64%, N 12.36%, O 14.12%.

Description and references

Prepn and pharmacology: F. Baroli et al., Arzneim.-Forsch. 13, 884 (1963).

Chemical structure

Properties

Crystalline powder, mp 164°. Practically insol in water. LD50 in mice (mg/kg): 1941 ±108 i.p., 10,000 ±615 orally; in rats (mg/kg): 1500 ±21 i.p. (Baroli).

Derivative

Hydrochloride.

Nomenclature

A-350; ICI-350.
C10H11ClN2O2.HCl; mol wt 263.12.
C 45.65%, H 4.60%, Cl 26.95%, N 10.65%, O 12.16%.

Properties

Crystals, mp 209-210°. Sol in water. LD50 in mice (mg/kg): 924 ±13 i.p., 2250 ±312 orally, 293 ±16 i.v., 1188 ±44 s.c.; in rats (mg/kg): 607 ±14 i.p., 1958 ±126 orally (Baroli).

Derivative

Mixture with aminopyrine.

Nomenclature

Dereuma.

Therapeutic Category

Antipyretic; analgesic.

Keywords

Analgesic (Non-Narcotic); Antipyretic

Status

This monograph has been retired and is no longer subject to revision or update.