12-01046. Beclobrate [Archived]

Nomenclature

CAS number: 55937-99-0
2-[4-[(4-Chlorophenyl)methyl]phenoxy]-2-methylbutanoic acid ethyl ester; (±)-2-methyl-2-[p-(p′-chlorobenzyl)phenoxy]butyric acid ethyl ester; ethyl (±)-2-[[α-(p-chlorophenyl)-p-tolyl]oxy]-2-methylbutyrate; Sgd-24774; Beclipur (Siegfried); Turec (Novartis).
C20H23ClO3; mol wt 346.85.
C 69.26%, H 6.68%, Cl 10.22%, O 13.84%.

Description and references

Diphenylmethane derivative. Prepn: K. Thiele et al., DE 2461069; eidem, US 4483999 (1975, 1984 both to Siegfried); eidem, Arzneim.-Forsch. 29, 711 (1979). Preliminary clinical trial in hyperlipidemia: C. Najemnik et al., ibid. 31, 2168 (1981). Series of articles on pharmacology: ibid. 33, 1464-1472 (1983). Metabolism: W. Roth et al., ibid. 35, 244 (1985). Pharmacokinetics: I. Gikalov, U. Ifflaender, ibid. 37, 1065 (1987).

Chemical structure

Properties

Oil, bp0.01-0.1 200-204°. LD50 orally in mice: 8000 mg/kg (Thiele, 1979).

Therapeutic Category

Antilipemic.

Keywords

Antihyperlipoproteinemic; Fibrates

Status

This monograph has been retired and is no longer subject to revision or update.