12-01057. Benapryzine [Archived]

Nomenclature

CAS number: 22487-42-9
α-Hydroxy-α-phenylbenzeneacetic acid 2-(ethylpropylamino)ethyl ester; benzilic acid 2-(ethylpropylamino)ethyl ester; 2-(ethyl-n-propylamino)ethyl α,α-diphenylglycolate.
C21H27NO3; mol wt 341.44.
C 73.87%, H 7.97%, N 4.10%, O 14.06%.

Description and references

Anticholinergic. Prepn: NL 6409696 corresp to M. D. Mehta, J. G. Bainbridge, US 3746743 (1963, 1973 to Beecham). Pharmacology: D. M. Brown et al., Nature 223, 416 (1969); C. Barthelemy et al., Therapie 27, 369 (1972); D. M. Brown et al., Br. J. Pharmacol. 47, 476 (1973). Metabolism: D. J. Jeffery et al., Xenobiotica 1, 169 (1971).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 3202-55-9
AP-1288; BRL-1288.
C21H27NO3.HCl; mol wt 377.90.
C 66.74%, H 7.47%, N 3.71%, O 12.70%, Cl 9.38%.

Properties

Rectangular plates from butanone, mp 164-166°.

Status

This monograph has been retired and is no longer subject to revision or update.