12-01118. Benzodepa [Archived]

Nomenclature

CAS number: 1980-45-6
[Bis(1-aziridinyl)phosphinyl]carbamic acid phenylmethyl ester; benzyl [bis(1-aziridinyl)phosphinyl]carbamate; benzyl bis(ethylenimido)phosphorourethan; benzcarbimine; AB-103; NSC-37096; Dualar (Armour Pharm.).
C12H16N3O3P; mol wt 281.25.
C 51.25%, H 5.73%, N 14.94%, O 17.07%, P 11.01%.

Description and references

Prepn: Bardos et al., Nature 183, 399 (1959); Papanastassiou, Bardos, J. Med. Pharm. Chem. 5, 1000 (1962).

Chemical structure

Properties

Crystals from benzene + cyclohexane, mp 134-135°. Practically insol in water. Soluble in fat solvents, peanut oil, other oils.

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic; Alkylating Agents; Aziridines

Status

This monograph has been retired and is no longer subject to revision or update.