12-02426. Clobuzarit [Archived]

Nomenclature

CAS number: 22494-47-9
2-[[4′-Chloro(1,1′-biphenyl)-4-yl]methoxy]-2-methylpropanoic acid; 2-[[p-(p-chlorophenyl)benzyl]oxy]-2-methylpropionic acid; ICI-55897; Clozic (ICI).
C17H17ClO3; mol wt 304.77.
C 67.00%, H 5.62%, Cl 11.63%, O 15.75%.

Description and references

Analog of clofibrate. Prepn: T. Leigh, L. A. McArdle, GB 1140748; eidem, US 3549690 (1969, 1970 both to ICI). Pharmacological studies: M. E. J. Billingham, Br. J. Pharmacol. 72, 523 (1981); M. E. J. Billingham et al., ibid. 551. Effects on platelet function in atherosclerosis: J. R. O'Brien et al., Thromb. Haemostasis 40, 75 (1978). Comparative clinical evaluation with penicillamine: D. Y. Bulgen et al., Ann. Rheum. Dis. 38, 567 (1979); H. A. Bird et al., Clin. Exp. Rheumatol. 1, 93 (1983).

Chemical structure

Properties

Crystals from benzene, mp 154-155°.

Therapeutic Category

Antirheumatic.

Status

This monograph has been retired and is no longer subject to revision or update.