12-03641. Epanolol [Archived]

Nomenclature

CAS number: 86880-51-5
N-[2-[[3-(2-Cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-4-hydroxybenzeneacetamide; 1-(2-cyanophenoxy)-3-β-(4-hydroxyphenylacetamido)ethylamino-2-propanol; ICI-141292.
C20H23N3O4; mol wt 369.41.
C 65.03%, H 6.28%, N 11.37%, O 17.32%.

Description and references

Cardio-selective β1-adrenergic blocker with intrinsic sympathomimetic activity. Prepn: L. H. Smith, DE 2362568; idem, US 4167581 (1974, 1979 both to ICI). Clinical pharmacology: T. H. Pringle et al., Br. J. Clin. Pharmacol. 21, 249 (1986). Clinical pharmacokinetics: I. D. Cockshott et al., Biopharm. Drug Dispos. 11, 253 (1990). Clinical evaluation in hypertension: B. Dahlof et al., Br. J. Clin. Pharmacol. 18, 831 (1984); in angina: J. Boberg et al., Clin. Cardiol. 15, 591 (1992).

Chemical structure

Properties

Crystals from acetonitrile, mp 118-120°.

Therapeutic Category

Antihypertensive; antianginal.

Keywords

β-Adrenergic Blocker; Antianginal; Antihypertensive; Aryloxypropanolamine Derivatives

Status

This monograph has been retired and is no longer subject to revision or update.