12-03759. Etersalate [Archived]

Nomenclature

CAS number: 62992-61-4
2-(Acetyloxy)benzoic acid 2-[4-(acetylamino)phenoxy]ethyl ester; 2-(4-acetamidophenoxy)ethyl 2-acetoxybenzoate; eterilate; etherylate; eterylate; Daital (Alter).
C19H19NO6; mol wt 357.36.
C 63.86%, H 5.36%, N 3.92%, O 26.86%.

Description and references

Deriv of aspirin. Prepn: C. S. Letelier, F. C. Grafulia, DE 2538206; eidem, US 4014921 (both 1977 to Alter); C. S. Letelier et al., Arch. Farmacol. Toxicol. 4, 153 (1978). Effect on in vitro platelet function in human plasma: M. P. Ortega et al., ibid. 6, 31 (1980). In vivo effects on primary immune response: I. Barasoain et al., Immunopharmacology 2, 293 (1980). Comparative toxicity study and gastric tolerance: S. Alonso et al., Arch. Farmacol. Toxicol. 4, 349 (1978).

Chemical structure

Properties

Cryst from methanol, mp 139-141°. LD10 orally in rats: 7000 mg/kg (Leterier, Grafulia, 1977).

Therapeutic Category

Analgesic; anti-inflammatory; antipyretic.

Keywords

Analgesic (Non-Narcotic); Anti-inflammatory (Nonsteroidal); Salicylic Acid Derivatives; Antipyretic

Status

This monograph has been retired and is no longer subject to revision or update.