12-03813. Ethylbenzhydramine [Archived]

Nomenclature

CAS number: 642-58-0
2-(Diphenylmethoxy)-N,N-diethylethanamine; 2-(benzhydryloxy)triethylamine; β-diethylaminoethyl benzhydryl ether; 2-(benzhydryloxy)-N,N-diethylethylamine; benzhydryl 2-diethylaminoethyl ether; etanautine.
C19H25NO; mol wt 283.41.
C 80.52%, H 8.89%, N 4.94%, O 5.65%.

Description and references

Anticholinergic. Prepn: Martin et al., US 2397799 (1946 to Geigy); Rieveschl, US 2421714 (1947 to Parke, Davis).

Chemical structure

Properties

bp0.15 140-142°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 86-24-8
C19H25NO.HCl; mol wt 319.87.
C 71.34%, H 8.19%, N 4.38%, O 5.00%, Cl 11.08%.

Properties

Prisms from alcohol + ethyl acetate, mp 140°. Bitter taste. Freely sol in water; sol in alcohol, acetone, chloroform; very slightly sol in benzene, ether. pH of 1% aq soln about 5.5.

Derivative

Methyl iodide.

Nomenclature

CAS number: 5982-52-5
C19H25NO.CH3I; mol wt 425.35.
C 56.47%, H 6.64%, N 3.29%, O 3.76%, I 29.84%.

Therapeutic Category

Antiparkinsonian.

Status

This monograph has been retired and is no longer subject to revision or update.