12-04171. Flumedroxone Acetate [Archived]

Nomenclature

CAS number: 987-18-8
(6α)-17-(Acetyloxy)-6-(trifluoromethyl)pregn-4-ene-3,20-dione; 17-hydroxy-6α-(trifluoromethyl)pregn-4-ene-3,20-dione acetate; 17-acetoxy-6α-(trifluoromethyl)progesterone; 17-hydroxy-6α-(trifluoromethyl)progesterone acetate; 6α-(trifluoromethyl)-17-hydroxyprogesterone acetate; WG-537; Demigran (Leo Pharm).
C24H31F3O4; mol wt 440.50.
C 65.44%, H 7.09%, F 12.94%, O 14.53%.

Description and references

Prepn: Godtfredsen, Vangedal, Acta Chem. Scand. 15, 1786 (1961); Godtfredsen, GB 905694 (1962 to Lvens Komiske Fabrik). Solubilization study: T. Lovgren et al., Acta Pharm. Suec. 15, 233 (1978).

Chemical structure

Properties

Solid, mp 206-207°. [α]D20 +30°. uv max (ethanol): 234 nm (ε 15600).

Therapeutic Category

Antimigraine.

Keywords

Antimigraine

Status

This monograph has been retired and is no longer subject to revision or update.