12-04805. Hydrargaphen [Archived]

Nomenclature

CAS number: 14235-86-0
[μ-[[3,3′-Methylenebis[2-naphthalenesulfonato]](2)]]diphenyldimercury; phenylmercuric methylenebis(2-naphthyl-3-sulfonic acid); phenylmercury 2,2′-dinaphthylmethane-3,3′-disulphonate; phenylmercuric dinaphthylmethanedisulfonate; methylenedinaphthylenesulfonic acid bisphenylmercuri salt; phenylmercury methylenedinaphthalenesulfonate; bis(phenylmercuri)methylenedinaphthalenesulfonate; phenyl mercuric Fixtan; Conotrane; P.M.F.; Versotrane; Hydraphen; Penotrane (WB Pharm.); Fibrotan; Septotan.
C33H24Hg2O6S2; mol wt 981.85.
C 40.37%, H 2.46%, Hg 40.86%, O 9.78%, S 6.53%.

Description and references

Prepn: Bywater, Pritchard, GB 584196 and GB 2555114 (1949, 1951 both to Ward, Blenkinsop). Bacteriostatic activity: A. A. Goldberg et al., J. Pharm. Pharmacol. 2, 20 (1950). Review and properties: Goldberg, Manuf. Chem. 22, 182 (1951); Hopf, ibid. 24, 444 (1953).

Chemical structure

Properties

Amorphous powder. Practically insol in water but readily goes into colloidal soln in alkali metal dinaphthylmethane disulfonates. The colloidal solns have strong tendency to absorb at interfaces and to form charged hydrated aggregates. LD50 orally in mice: 70 mg/kg (Goldberg).

Use

Bactericide and fungicide for the treatment of wool, hides, leather, textiles, timber and wood-pulp, paints, adhesives.

Therapeutic Category

Anti-infective (topical).

Keywords

Antiseptic/Disinfectant; Mercurial compounds

Status

This monograph has been retired and is no longer subject to revision or update.