12-05476. Leucinocaine Mesylate [Archived]

Nomenclature

CAS number: 135-44-4
2-(Diethylamino)-4-methyl-1-pentanol 4-aminobenzoate (ester) monomethanesulfonate (salt); 2-diethylamino-4-methylpentyl p-aminobenzoate methanesulfonate; p-aminobenzoic acid β-diethylaminoisohexyl ester methanesulfonate; p-aminobenzoic acid N,N-diethylleucinol ester methanesulfonate; p-aminobenzoyl-N-1-diethylamino-1-isobutylethanol methanesulfonate; 2-methyl-4-diethylaminopentan-5-ol p-aminobenzoate; Panthesin (Novartis).
C18H32N2O5S; mol wt 388.52.
C 55.65%, H 8.30%, N 7.21%, O 20.59%, S 8.25%.

Description and references

Prepn: Lebeau, Janot, Traité de Pharmacie Chimique vol. III (Masson et Cie, Paris, 1955-1956) p 1296. Prepn of hydrochloride: Karrer, US 1555217 and see also DE 464484 (1925, 1928 to Chem. Fabrik Flora). Efficacy and toxicity in animals: R. N. Bieter et al., J. Pharmacol. Exp. Ther. 57, 221 (1936).

Chemical structure

Properties

Crystals, mp 171°. Sol in 3 parts water, alcohol. Practically insol in ether, petr ether, ethyl acetate, acetone, benzene. MLD in rabbits (mg/kg): 20 i.v.; 10.8 intraspinally (Bieter).

Therapeutic Category

Anesthetic (local).

Keywords

Anesthetic (Local)

Status

This monograph has been retired and is no longer subject to revision or update.