12-05737. Magnoline [Archived]

Nomenclature

CAS number: 6859-66-1
1,2,3,4-Tetrahydro-1-[[4-[2-hydroxy-5-[(1,2,3,4-tetrahydro-7-hydroxy-6-methoxy-2-methyl-1-isoquinolinyl)methyl]phenoxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol.
C36H40N2O6; mol wt 596.71.
C 72.46%, H 6.76%, N 4.69%, O 16.09%.

Description and references

From bark of Magnolia macrophylla Michx. and M. fuscata Andr., Magnoliaceae: Lloyd, Am. J. Pharm. 1891, 438; Proskurnina, Orékhov, Bull. Soc. Chim. Fr. 5, 1357 (1938). Structure: eidem, C.A. 35, 25209 (1941).

Chemical structure

Properties

Crystals, mp 178-179°. [α]D 9.6° (pyridine). Slightly sol in alcohol, acetone, chloroform; practically insol in water, benzene, ether.

Derivative

Trimethyl ether.
C39H46N2O6; mol wt 638.79.
C 73.33%, H 7.26%, N 4.39%, O 15.03%.

Properties

Crystals, mp 109-110°.

Status

This monograph has been retired and is no longer subject to revision or update.