12-06179. Methylol Riboflavine [Archived]
Description and references
Mixture of methylol (CH2OH) derivatives of riboflavine formed by the action of formaldehyde on riboflavine in weakly alkaline soln. The number of methylol groups in the ribityl moiety varies from 1 to 3. Prepn: Schoen, Gordon, Arch. Biochem. 22, 149 (1949); US 2587533 (1952 to Endo Prod.).
Properties
Orange to yellow, hygroscopic powder. May have a slight odor of formaldehyde. Sol in water. Practically insol in alcohol, benzene, chloroform, ether. Dextrorotatory. The pH of a 10% aq soln is between 6.7 and 7.9. The dry powder is unstable and loses its biological activity in the course of several months with the liberation of formalde-hyde and the partial formation of products practically insol in water.Status
This monograph has been retired and is no longer subject to revision or update.