12-06439. Nafiverine [Archived]

Nomenclature

CAS number: 5061-22-3
α-Methyl-1-naphthaleneacetic acid 1,4-piperazinediyldi-2,1-ethanediyl ester; 1,4-piperazinediethanol bis(α-methyl-1-naphthaleneacetate); N,N′-bis[[2-(1-naphthyl)propionyloxy]ethyl]piperazine; N,N′-di[α-(1-naphthyl)propionyloxy-2-ethyl]piperazine; Naftidan.
C34H38N2O4; mol wt 538.68.
C 75.81%, H 7.11%, N 5.20%, O 11.88%.

Description and references

Prepn: Pala, GB 1016968 (1966 to de Angeli). Isoln and characterization of isomers: Pala, Montegani, Farmaco Ed. Sci. 22, 3 (1967).

Chemical structure

Derivative

Dihydrochloride.
C34H40Cl2N2O4; mol wt 611.60.
C 66.77%, H 6.59%, Cl 11.59%, N 4.58%, O 10.46%.

Properties

Crystals, mp 220-221°.

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic

Status

This monograph has been retired and is no longer subject to revision or update.