12-06668. Nitrefazole [Archived]

Nomenclature

CAS number: 21721-92-6
2-Methyl-4-nitro-1-(4-nitrophenyl)-1H-imidazole; 1-(4-nitrophenyl)-2-methyl-4-nitroimidazole; EMD-15700; Altimol (Merck KGaA).
C10H8N4O4; mol wt 248.19.
C 48.39%, H 3.25%, N 22.57%, O 25.79%.

Description and references

Aldehyde dehydrogenase inhibitor. Prepn: R. Klink, L. Hepding, GB 1133408; eidem, US 3491105 (1968, 1970 to E. Merck). Use as alcohol deterrent: A. Behpour et al., DE 2645709; eidem, US 4182770 (1978, 1980 to E. Merck). Effect on enzyme activity: C. A. Seyfried et al., Alcohol. Clin. Exp. Res. 6, 313 (1982). Effect on ethanol consumption: D. E. McMillan, Drug Dev. Res. 3, 193 (1983). Clinical studies: R. Dusing et al., Arzneim.-Forsch. 32, 903 (1982); D. Roscher, W. Poser, ibid. 905.

Chemical structure

Properties

Crystals from acetone, mp 185-187°.

Therapeutic Category

Alcohol deterrent.

Keywords

Alcohol Deterrent

Status

This monograph has been retired and is no longer subject to revision or update.