12-07693. Plegatil [Archived]

Nomenclature

CAS number: 53597-29-8
N,N-Diethyl-N-methyl-2-[2-(trimethylammonio)ethoxy]-1-propanaminium diiodide; N,N-diethyl-N,N′,N′,N′-tetramethyl-N,N′-(2-methyl-3-oxapentamethylene)bis[ammonium iodide]; 2-(2-dimethylaminoethoxy)-N,N-diethylpropylamine dimethiodide; β-dimethylaminoethyl β′-diethylamino-α′-methylethyl ether dimethiodide; 2-dimethylaminoethyl 2′-diethylaminoisopropyl ether bismethiodide; HL-8731.
C13H32I2N2O; mol wt 486.21.
C 32.11%, H 6.63%, I 52.20%, N 5.76%, O 3.29%.

Description and references

Ganglionic blocking agent. Prepd but not claimed: G. Pakleppa, D. Lenke, DD 11363 (1956), C.A. 53, 2094i (1959). Pharmacology: D. Lenke, Arzneim.-Forsch. 7, 616 (1957); ibid. 11, 571 (1961).

Chemical structure

Properties

Crystals, mp 178-180°. LD50 in mice (mg/kg): 39.1 i.v., 1125 orally (Lenke, 1957).

Status

This monograph has been retired and is no longer subject to revision or update.