12-08632. Sikkimotoxin [Archived]

Nomenclature

CAS number: 18651-67-7
3a,4,9,9a-Tetrahydro-4-hydroxy-6,7-dimethoxy-9-(3,4,5-trimethoxyphenyl)naphtho[2,3-c]furan-1(3H)-one; 1-hydroxy-2-hydroxymethyl-6,7-dimethoxy-4-(3′,4′,5′-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalene-3-carboxylic acid lactone.
C23H26O8; mol wt 430.45.
C 64.18%, H 6.09%, O 29.74%.

Description and references

Isoln from roots and rhizomes of Podophyllum sikkimensis R. Chatterjee et Mukerjee, Berberidaceae: Chatterjee, Datta, Indian J. Physiol. Allied Sci. 4, 61 (1950). Structure: Chatterjee, Chakravarti, J. Am. Pharm. Assoc. Sci. Ed. 41, 415 (1952); Schreier, Helv. Chim. Acta 47, 1529 (1964).

Chemical structure

Properties

Crystals from ethanol + benzene, mp 120°. [α]D25 91.8°. Freely sol in ethanol, methanol, chloroform. Sparingly sol in benzene. Practically insol in water and petr ether.

Status

This monograph has been retired and is no longer subject to revision or update.