12-08918. Spizofurone [Archived]

Nomenclature

CAS number: 72492-12-7
5-Acetylspiro[benzofuran-2(3H),1′-cyclopropan]-3-one; AG-629; Maon (Takeda).
C12H10O3; mol wt 202.21.
C 71.28%, H 4.98%, O 23.74%.

Description and references

Prepn: H. Sugihara et al., EP 3084; eidem, US 4284644 (1979, 1981 both to Takeda); M. Kawada et al., Chem. Pharm. Bull. 32, 3532 (1984). One step synthesis: M. Watanabe et al., ibid. 3373. Anti-ulcerative effect in animals: N. Inatomi et al., Arzneim.-Forsch. 35, 1553 (1985). Cytoprotective effects on rat gastric mucosa: eidem, Eur. J. Pharmacol. 112, 81 (1985). Stimulation of endogenous prostaglandin synthesis in vitro: I. Inada et al., ibid. 124, 149 (1986).

Chemical structure

Properties

Crystals from ethanol, mp 102-104° (Kawada); also reported as mp 106-107° (Watanabe).

Therapeutic Category

Antiulcerative.

Keywords

Antiulcerative; Cytoprotectant (Gastric)

Status

This monograph has been retired and is no longer subject to revision or update.