12-09743. Tribromoethanol [Archived]

Nomenclature

CAS number: 75-80-9
Tribromoethyl alcohol.
C2H3Br3O; mol wt 282.76.
C 8.50%, H 1.07%, Br 84.78%, O 5.66%.
Br3CCH2OH.

Description and references

Prepd by the reduction of bromal with aluminum isopropylate: US 1572742 (1926); US 1725054 (1929); US 1882944 (1932). Acute toxicity: R. R. Burtner, G. Lehmann, J. Pharmacol. Exp. Ther. 63, 183 (1938).

Properties

Crystals, mp 79-82°, decompn starting at 70°. bp10 92-93°. Slight ethereal or aromatic odor and taste. Sol in 40 parts water at 40°; sol in alcohol, ether, benzene, warm petr ether; very sol in amylene hydrate. The aq and alcoholic solns dec on exposure to light; in aq soln dibromoacetaldehyde and HBr are formed, both of which are strongly irritant. Protect from light. LD50 orally in rats: 1.09 g/kg (Burtner, Lehmann).

Derivative

Solution in amylene hydrate.

Nomenclature

Bromethol; Avertin (Winthrop).

Therapeutic Category

Has been used as a basal anesthetic.

Therapeutic Category (Veterinary)

Has been used as a general anesthetic and narcotic.

Status

This monograph has been retired and is no longer subject to revision or update.