Nomenclature
CAS number: 9040-14-6
Description and references
Group of peptide lactones produced by Streptomyces loidensis: Donovick et al., US 2990325 (1961 to Olin Mathieson). Antimicrobial antibiotic structurally similar to virginiamycin
S1: Bodanszky, Ondetti, Antimicrob.
Agents Chemother. 1963, 360. Identity with
pristinamycins: Preud'homme et al., Bull. Soc. Chim. Fr. 1968, 585. Nomenclature:
Crooy, De Neys, J. Antibiot. 25, 371 (1972).
Properties
Crystals, dec 130-135°. [α]D25 72°. uv max (methanol): 230 nm (E1%1cm 590). Sol in methanol,
ethanol, isopropanol, butanol, acetone, methyl ethyl ketone, ethyl
acetate, amyl acetate, ether, dioxane, dimethylformamide, benzene,
acetic acid; slightly sol in water, hexane.Derivative
Vernamycin Bα see Mikamycin B.Derivative
Vernamycin Bβ.
Nomenclature
CAS number: 57206-54-9
4-[
N-Methyl-4-(methylamino)-
l-phenylalanine]virginiamycin
S
1; ostreogrycin B
2; pristinamycin I
B.
Derivative
Vernamycin Bγ.
Nomenclature
CAS number: 28979-74-0
2-
d-Alanine-4-[4-(dimethylamino)-
N-methyl-
l-phenylalanine]virginiamycin S
1; ostreogrycin B
1; pristinamycin I
C.
Derivative
Vernamycin Bδ.
Nomenclature
CAS number: 29139-17-1
2-
d-Alanine-4-[
N-methyl-4-(methylamino)-
l-phenylalanine]virginiamycin S
1.
Status
This monograph has been retired and is no longer subject
to revision or update.