12-10319. Zolamine [Archived]

Nomenclature

CAS number: 553-13-9
N-[(4-Methoxyphenyl)methyl]-N′,N′-dimethyl-N-2-thiazolyl-1,2-ethanediamine; 2-[(2-dimethylaminoethyl)(p-methoxybenzyl)amino]thiazole; N′,N′-dimethyl-N-(2-thiazolyl)-N-(p-methoxybenzyl)ethylenediamine.
C15H21N3OS; mol wt 291.41.
C 61.82%, H 7.26%, N 14.42%, O 5.49%, S 11.00%.

Description and references

Antihistamine with local anesthetic properties. An isostere of pyrilamine and is prepd accordingly: Shigeya Saijo, J. Pharm. Soc. Jpn. 72, 1009 (1952).

Chemical structure

Properties

Oily liquid. Putrid odor. bp7 217-219°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 1155-03-9
194-B; WL-291.
C15H21N3OS.HCl; mol wt 327.87.
C 54.95%, H 6.76%, N 12.82%, O 4.88%, S 9.78%, Cl 10.81%.

Properties

Odorless crystals from alc. Slightly bitter taste. mp 167.5-167.8°. Sol in water.

Status

This monograph has been retired and is no longer subject to revision or update.