13-01040. Benfurodil Hemisuccinate [Archived]

Nomenclature

CAS number: 3447-95-8
Butanedioic acid mono[1-[5-(2,5-dihydro-5-oxo-3-furanyl)-3-methyl-2-benzofuranyl]ethyl] ester; succinic acid monoester with 4-[2-(1-hydroxyethyl)-3-methyl-5-benzofuranyl]-2(5H)-furanone; 2-[1-(succinoyloxy)ethyl]-3-methyl-5-(2-oxo-2,5-dihydro-4-furyl)benzo[b]furan; 2-(1-hydroxyethyl)-β-(hydroxymethyl)-3-methyl-5-benzofuranacrylic acid γ-lactone hydrogen succinate; benzofurodil; Eucilat (Sanofi).
C19H18O7; mol wt 358.34.
C 63.68%, H 5.06%, O 31.25%.

Description and references

Prepn: J. Schmitt, FR 1408721; idem, US 3355463 (1965, 1967 to Clin-Byla). Prepn and toxicity: J. Schmitt et al., Bull. Soc. Chim. Fr. 1967, 74. Synthesis and pharmacology: eidem, Chim. Ther. 1, 305 (1966).

Chemical structure

Properties

White to pale yellow crystals from ethyl acetate, mp 144°. Sol in alkaline solns. LD50 in mice: 550 mg/kg orally (Schmitt).

Therapeutic Category

Vasodilator (peripheral).

Keywords

Cardiotonic; Vasodilator (Coronary)

Status

This monograph has been retired and is no longer subject to revision or update.