13-01522. Butidrine Hydrochloride [Archived]

Nomenclature

CAS number: 1506-12-3
5,6,7,8-Tetrahydro-α-[[(1-methylpropyl)amino]methyl]-2-naphthalenemethanol hydrochloride; α-[(sec-butylamino)methyl]-5,6,7,8-tetrahydro-2-naphthalenemethanol hydrochloride; butydrine hydrochloride; Betabloc (Farmasimes); Recetan (Simes).
C16H26ClNO; mol wt 283.84.
C 67.70%, H 9.23%, Cl 12.49%, N 4.93%, O 5.64%.

Description and references

β-Adrenergic blocker. Prepn: Ferrari et al., Boll. Chim. Farm. 103, 32 (1964), C.A. 61, 5580d (1964); FR 1390056 (1965 to Holding Ceresia), C.A. 62, 16162d (1965). Pharmacology: R. Ferrini, Arzneim.-Forsch. 18, 48 (1968). Brief review of butidrine and other β-blockers: A. M. Karow et al., Prog. Drug Res. 15, 103-122 (1971).

Chemical structure

Properties

Crystals, mp 129-130°. LD50 in mice (mg/kg): 20.2 i.v.; 235 orally (Ferrini).

Therapeutic Category

Antiarrhythmic.

Keywords

β-Adrenergic Blocker; Antiarrhythmic

Status

This monograph has been retired and is no longer subject to revision or update.